Press Release: Announcing the Launch of Our New Website

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LDF Research Dr. Garon

Claude Garon, Ph.D., Chief, RML, National Institute of Allergy and Infectious Diseases, National Institutes of Health. The Antigen test proved to be highly successful as a direct detection test and NIH eventually stopped funding it.

Overview of LDF Sponsored Research

The LDF has funded over $500,000 in research since 1988. This includes research grants to outside investigators (extramural) and for internal research programs (intramural).

Over 40+ scientific publications have resulted from this funding and an additional 138 articles have appeared in the LDF's Journal of Spirochetal & Tickborne Diseases. Simply funding research is not enough. Researchers need to interact and challenge each other’s theories to find the truth.

When NIH would not fund research into a new test located in Rocky Mountain Labs, the LDF funded it! You can view a statement about this by Dr. Claude Garon in the video in the research section.

The LDF facilitates research presentations at our 27 LDF scientific conferences and publications {e.g. LDF's Journal of Spirochetal & Tickborne Diseases (“JSTD”), and Clinical Infectious Diseases (“CID”) supplement] are major ways to educate thousands of researchers and healthcare professionals as well as stimulate research.

Click here to link to the JSTD and CID in the Scientific Education section.

There are numerous other ways the LDF Facilitates Research:

  • Conducts Scientific Conferences, medical lectures, and Poster presentations which allows researchers and healthcare professionals the opportunity to present and debate the latest findings, forge new collaborations, and secure funding.
  • Publishes the Journal of Spirochetal and Tick-borne Diseases provides an avenue for researchers to publish the latest science, debate research, and review historically important but out-of-circulation literature. JSTD internet articles receive about 7,000 views a month.
  • Ensures that science is internationally accessible to healthcare professionals, and the public by posting of the JSTD and Medical Conferences on its website.
  • LDF has funded medically accredited summaries of its conference presentations on Medscape, which awarded CMEs to 500 additional physicians who could not attend the conference in person.
  • LDF worldwide networks help scientists and clinicians find collaborators. Conducts & Funds Research through a peer-reviewed grant process.
  • In 1998, Dr. Irwin Vanderhoof presented landmark LDF research that proved women given amoxicillin during pregnancy prevented infection of the fetus and decreased the risk of fetal loss. (see the Pregnancy & Lyme presentation in the Education section. Chose Scientific Education and then Select the Pregnancy Option.

Grant Peer-Review Process

Step 1. Research Review Committee

Julie Rawling, MPH is the Scientific Review Chairman and coordinates the evaluation and scoring of all proposals. This peer-review process ensures that critical steps in the investigative process are met, increasing the likelihood of a successful outcome.

Step 2. Selection Committee

This committee of patients and scientists make the final funding decision based on the recommendations by the scientific reviewers and needs of the healthcare provider and patient communities.

Grant Funding Options

  • Project Grants: Specific project funding is available. Preference is given to smaller grant requests (e.g. $20,000) for scientifically important research.
  • Salary Grants: Grants to cover salaries usually fund multiple projects. This is especially beneficial in the development of new researchers.

Donors of $20,000 or more can designate funds to their choice of approved proposals or funding areas. Also, the LDF will solicit new requested project proposals, when the donation is enough to cover the desired grant activity. All grants must be approved by the Research Review Committee. All projects must be initiated and completed within the time frame of the funding. The LDF does not fund overhead nor indirect costs. Resulting publications must include the funded individual's name as an author, credit to the LDF for funding, and give preference to the JSTD for publication rights.

Research Grants have included

  • Development of Improved tests
  • Vaccine models
  • LD in pregnancy
  • Pathogenesis of LD
  • Tick testing
  • LD in dogs
  • LD in cats
  • Neurologic LD
  • Tick vectors in North America
  • New Borrelia in lone star ticks

Internal Research

  • Pregnancy Registry - A multi-year registry for women diagnosed with Lyme disease during their pregnancy & examining the outcomes of both mothers and babies after
  • treatment.
  • Physician Preferences in Diagnosis & Treatment
  • Poster presentations and a major publication.
  • Cost of Lyme Disease to Society - A major research collaboration with the Society of Actuaries and New York University School of Business.
Karen Vanderhoof-Forschner holding a vial of ticks

LDF President, Karen V-Forschner collecting the first infected ticks with John

Post, DVM, from around her house in Stamford, Ct.

Karen then alerted the Stamford health department to the findings. That health department alerted the community. Karen then held and LDF scientific conference in the area to educate the doctors about the disease.

Supporting research by supporting the Armed Forces since 1989. Karen is on the right and LDF Board member Dr. Paul Duray is on the left. Dr. Duray was conducting a Lyme Disease Project for the military.

LDF External Grant-related Publications, excluding the journal articles in Clinical Infectious Diseases, and The Journal of Spirochetal and Tick-borne Diseases.

  1. Anderson JF, DA Miller, JE Post, RC Johnson, LA Magnarelli, TG Andrealis. Isolation of Leptospira interrogans serovar grippotyphosa from the skin of a dog. Journal of the American Veterinary Medical Association. 1993. 203:1550-1551.
  2. Barbour AG, D Fish. The biological and social phenomenon of Lyme disease. Science. 1993. 260:1610-1616.
  3. Bosler EM, RD Evans, EM Schneider. Biopsy of canine ear tissue for detection of Borrelia burgdorferi following Ixodes dammini feeding. FEMS Microbiol. 1992. 78(2-3):317-319.
  4. Bosler EM, RD Evans, EM Schneider, RB LeFebrve. Experimental Borrelia burgdorferi infection and temporal immune responses in dogs. VI International Conference on Lyme Borreliosis. 1994. Bologna, Italy. Abstract P042M.
  5. Edwards JF, MD Gibson, MT Omran, CR Young. Proctitis and colitis in cats
    experimentally infected with Borrelia burgdorferi. Annual Meeting of American College of Veterinary Pathologists. Dec 8, 1993. San Antonio, Texas. Abstract/Poster.
  6. Evans RD, EM Bosler, F Orthel, JL Robertson, EM Schneider, RB LeFebrve, MD Graham. Canine Lyme borreliosis I. Gross clinical observations of laboratory beagles following exposure to ticks infected with Borrelia burgdorferi. Journal of Spirochetal and Tick-borne Diseases. 1995. 2(2):28- 33.
  7. Evans RD, JL Robertson, MD Graham, EM Bosler, RB LeFebrve, EM Schneider. Canine Lyme borreliosis II. Minimal lesions in tisues of laboratory beagles following infection by exposure to Ixodid ticks infected with Borrelia burgdorferi. Journal Spirochetal and Tick-borne Diseases. 1995. 2(2):33-37.
  8. Feder BM, RJ Joseph, SD Moroff, EM Schneider, EM Bosler. Borrelia burgdorferi antibodies in canine cerebrospinal fluid. Proceedings of the American College of Veterinary Internal Medicine. May 1991. New Orleans, LA.
  9. Feir D, CR Santanello, B Li, Ch Xie, E Masters, R Marconi, G Weil. Evidence supporting the presence of Borrelia burgdorferi in Missouri. Am J Trop Med Hyg. 1994. 51(4):475-482.
  10. Gebbia, JA, EM Bosler, RD Evans, EM Schneider. Acquired resistance in dogs to repeated infestation with Ixodes scapularis (Acari: Ixodidiae) reduces tick viability and reproductive success. Jour. Exp. Appl. Acarol. 1995. 19(10):593-605.
  11. Gibson MD, CR Young, MT Omran, K Palma, JF Edwards, JA Rawlings. Lyme disease in an experimental cat model. In: Lyme Borreliosis (NATO Asi Series A: Life Sciences. Axford JS, Rees DHE (eds.), Plenum Press, New York, 1994. 260:187-199.
  12. Gibson MD, CR Young, MT Omran, et al. Lyme disease in an experimental cat model. International Journal of Angiology. 1995. 4:155-159.
  13. Gibson MD, MT Omran, CR Young. Experimental feline Lyme borreliosis as a model for testing Borrelia burgdorferi vaccines in immunobiology of proteins and peptides. In: Lyme Borreliosis, MZ Atassi and GS Bixler Jr. (eds), Plenum Press, New York, 1995.
  14. Gibson MD, CR Young, MT Omran, et al. Borrelia burgdorferi infection in cats. JAVMA. 1993. 202:1786.
  15. Gibson MD, CR Young, MT Omran, K Palma, J Rawlings. Lyme disease in an experimental cat model. Ann Rheum Dis. 1993. 52:408. Abstract/Poster.
  16. Gibson MD, CR Young, MT Omran, K Palma, JA Rawlings. Lyme Disease in an experimental cat model. Special International Symposium on Lyme Borreliosis - International College of Angiology. July 3-10, 1993. Copenhagen, Denmark. Abstract/Poster.
  17. Gibson MD, CR Young, MT Omran, K Palma, and JA Rawlings. Lyme disease in an experimental cat model. Second European Symposium on Lyme Borreliosis. May 19-20, 1993. London, United Kingdom. Abstract/Poster.
  18. Gibson MD, MT Omran, CR Young, JA Rawlings, C David, K Palma. Lyme disease in experimental animals using Borrelia burgdorferi isolate 532 obtained from 5 cat fleas. Xth Texas Immunology Conference. Nov 13-15, 1992. Richardson, Tx. Poster.
  19. Gibson MD, MT Omran, CR Young, et al. Lyme disease in a domestic cat model. Proceedings of the Third International Symposium on Ectoparasites of Pets. April 2-4, 1995. College Station, Texas. Abstract/Poster.
  20. Liegner KB, MH Ziska, MD Agricola, JD Hubbard, MS Klempner, PK Coyle, ME Bayer, and PH Duray. Fatal chronic meningoencehpalomyelitis (CMEM) with massive hydrocephalus, in a New York state patient with evidence of Borrelia burgdorferi (Bb) exposure. International Conf. on Lyme Borreliosis. 1994. Bologna, Italy. Abstract Po41T.
  21. Mandel NS, EM Schneider, EM Bosler, EG Senker. Intrathecal production of Borrelia burgdorferi specific antibodies in a dog with central nervous system Lyme borreliosis. The Compendium on Continuing Education for Veterinarian. 1993. 15(4):581-589.
  22. Mandel NS, EG Senker, EM Bosler, EM Schneider. Intrathecal production of Borrelia burgdorferi-specific antibodies in a dog with central nervous system Lyme borreliosis. Small Animal: Compendium. 1993. 15:581-586.
  23. Omran MT. Humoral and histopathologic responses to Borrelia burgdorferi in a feline model. College of Veterinary Medicine, Texas A&M University. 1995. PhD Dissertation.
  24. Omran MT, Cr Young, MD Gibson, DJ Oestmann. Feline Lyme borreliosis. In: Consultations in Feline Internal Medicine 3. JR August editor. Philadelphia: Saunders, 1997. 23-30.
  25. Rawlings JA, GJ Teltow. Prevalence of Borrelia (Spirochaetaceae) spirochetes in Texas ticks. J Med Entomol. 1994. 31(2):297-301.
  26. Sadziene A, PA Thompson, and AG Barbour. In vitro inhibition of B. burgdorferi growth by antibodies. Journal of Infectious Diseases. 1993. 167: 165-72.
  27. Vanderhoof IT, K Vanderhoof-Forschner. Lyme disease: The Cost to Society. Contingencies. 1993. 5(1):42-48.
  28. Whitmire W, C Garon. Specific and nonspecific responses of murine B cells to membrane blebs of Borrelia burgdorferi. Infection and Immunity. 1993. 61:1460-
    1467.
  29. Ziska MH, ST Donta, FC Demarest. Physician preferences in the diagnosis and treatment of Lyme disease in the United States. Infection. 1996. 24(2): 82-86.
  30. Ziska MH, FC Demarest, ST Donta. Physician preferences in Lyme borreliosis treatment in the US Symposium on the Therapy and Prophylaxis for Lyme Borreliosis. 1995. Portoroz, Slovenia. Abs. P12.
  31. Ziska MH, T Giovanello, MJ Johnson, J Baly. Disseminated Lyme disease and pregnancy. IX Annual International Conference on Lyme Borreliosis & other Tick-borne Disorders. 1996. Mass. USA.

    Clinical Infectious Diseases - LDF Supplement

  32. Aberer E, F Koszik, M Silberer. Why is chronic Lyme borreliosis chronic? Clin Infect Dis. 1997. 25(suppl 1): S64-70.
  33. Barthold SW, S Feng, LK Bockenstedt, E Fikrig, K Feen. Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi. Clin Infect Dis. 1997. 25(suppl 1): S9-17.
  34. Bosler EM. Introduction. 1997. Clin Infect Dis. 25(suppl 1): S1-2.
  35. Donta ST. Tetracycline therapy for chronic Lyme disease. Clin Infect Dis. 1997. 25(suppl 1): S52-56.
  36. Dorward DW, ER Fischer, DM Brooks. Invasion and cytopathic killing of human lymphocytes by spirochetes causing Lyme disease. Clin Infect Dis. 1997. 25(suppl 1): S2-8.
  37. Dumler SJ. Is human granulocytic ehrlichiosis a new Lyme disease? Review and comparison of clinical, laboratory, epidemiological, and some biological features. Clin Infect Dis. 1997. 25(suppl 1): S43-47.
  38. Fallon BA, S Das, JJ Plutchok, F. Tager, K Liegner, R Van Heertum. Functional brain imaging and neuropsychological testing in Lyme disease. Clin Infect Dis. 1997. 25(suppl 1): S57-63.
  39. Lubke LL, CF Garon. The antimicrobial agent melittin exhibits powerful in vitro inhibitory effects on the Lyme disease spirochete. Clin Infect Dis. 1997. 25(suppl 1): S48-51.
  40. Meurice F, D Parenti, D Fu, DS Krause. Specific issues in the design and implementation of an efficacy trial for a Lyme disease vaccine. Clin Infect Dis. 1997. 25(suppl 1): S71-75.
  41. Pavia CS, GP Wormser, Gary Norman. Activity of sera from patients with Lyme disease against Borrelia burgdorferi. Clin Infect Dis. 1997. 25(suppl 1): S25-30.
  42. Persing DH. The cold zone: A curious convergence of tick-transmitted diseases. Clin Infect Dis. 1997. 25(suppl 1):S35-42.
  43. Tilton RC, MN Sand, M Manak. The Western immunoblot for Lyme disease: Determination of Sensitivity, specificity, and interpretive criteria with use of commercially available performance panels. Clin Infect Dis. 1997. 25(suppl 1): S31-34.
  44. Weis JJ, L. Yang, KP Seiler, RM Silver. Pathological manifestations in murine Lyme disease: Association with tissue invasion and spirochete persistence. Clin Infect Dis. 1997. 25(suppl 1): S18-24

    Recent Presentations of Internal Research

  45. Karen Vanderhoof-Forschner, The Scientific History of Lyme disease, International Lyme and Associated Diseases Society, Annual Conference, Mass. 2018.
  46. Karen Vanderhoof-Forschner, Lyme Disease Cost to Society, International Lyme and Associated Diseases Society, 9th European Scientific Conference, Spain. Poster Presenter, 2019.
  47. Karen Vanderhoof-Forschner, Cost to Society, applying the New CDC Case Count Formula, Poster presented at LymeMind, 2019.
  48. Martina Ziska, MD, Pregnancy & Lyme. Boston
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